Computer simulation of acidosis-induced abnormal repolarization and repetitive activity in dog Purkinje fibers.


Equations described by Mc Allister et al. (1975) were used to simulate the abnormal repolarization phase of the action potential (early after depolarization or hump), which often occurs in isolated dog Purkinje fibers submitted to acid media and can result in re-excitation. The development of humps was simulated by modifying the īK2-Em relationship in such… (More)


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