Computer simulation of T3/T7 phage infection using lag times.

  title={Computer simulation of T3/T7 phage infection using lag times.},
  author={Frank Buchholtz and F. W. Schneider},
  journal={Biophysical chemistry},
  volume={26 2-3},
A minimal mechanism is proposed which describes the transcriptional and translational processes for four phage proteins (RNA polymerase, DNase, primase and DNA polymerase) involved in T3/T7 DNA replication. Phage DNA replication is also included. It is shown how lag times may be incorporated into a kinetic mechanism. The distinct three-stage transport of phage DNA into the bacterial host (E. coli) is considered. DNA transport is assumed to be rate-determining for the transcription of class I… CONTINUE READING

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