Computer-simulation methods in human linkage analysis.

  title={Computer-simulation methods in human linkage analysis.},
  author={J{\"u}rg Ott},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={86 11},
  • Jürg Ott
  • Published 1989 in
    Proceedings of the National Academy of Sciences…
In human linkage analysis, many statistical problems without analytical solution could be solved by ad hoc Monte Carlo procedures were efficient computer-simulation methods available for members of family pedigrees. In this paper, a general method is described for randomly generating genotypes at one or more marker loci, given observed phenotypes at loci… CONTINUE READING