Computer modelling of DNA structures involved in chromosome maintenance.

@article{Eckdahl1987ComputerMO,
  title={Computer modelling of DNA structures involved in chromosome maintenance.},
  author={Todd T. Eckdahl and John N. Anderson},
  journal={Nucleic acids research},
  year={1987},
  volume={15 20},
  pages={
          8531-45
        }
}
Sequence-dependent DNA bending of synthetic and natural molecules was studied by computer analysis. Modelling of synthetic oligonucleotides and of 107 kb of natural sequences gave results which closely resembled published electrophoretic data, demonstrating the powerful predictive capacity of the procedure. The analysis was extended to the study of DNA structures involved in chromosome maintenance. Centromeric DNAs from yeast were found to have sequences in their functional elements which cause… CONTINUE READING

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