Computer control of gene expression: Robust setpoint tracking of protein mean and variance using integral feedback

Abstract

Protein mean and variance levels in a simple stochastic gene expression circuit are controlled using proportional integral feedback. It is shown that the protein mean level can be globally and robustly tracked to any desired value using a simple PI controller that satisfies explicit sufficient conditions. Controlling both the mean and variance requires on… (More)
DOI: 10.1109/CDC.2012.6426720

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@article{Briat2012ComputerCO, title={Computer control of gene expression: Robust setpoint tracking of protein mean and variance using integral feedback}, author={Corentin Briat and Mustafa Khammash}, journal={2012 IEEE 51st IEEE Conference on Decision and Control (CDC)}, year={2012}, pages={3582-3588} }