Computer-based redesign of a protein folding pathway

@article{Nauli2001ComputerbasedRO,
  title={Computer-based redesign of a protein folding pathway},
  author={Sehat Nauli and Brian Kuhlman and David Baker},
  journal={Nature Structural Biology},
  year={2001},
  volume={8},
  pages={602-605}
}
A fundamental test of our current understanding of protein folding is to rationally redesign protein folding pathways. We use a computer-based design strategy to switch the folding pathway of protein G, which normally involves formation of the second, but not the first, β-turn at the rate limiting step in folding. Backbone conformations and amino acid sequences that maximize the interaction density in the first β-hairpin were identified, and two variants containing 11 amino acid replacements… Expand
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