Computer-based design of novel protein structures.

  title={Computer-based design of novel protein structures.},
  author={Glenn L. Butterfoss and Brian Kuhlman},
  journal={Annual review of biophysics and biomolecular structure},
Over the past 10 years there has been tremendous success in the area of computational protein design. Protein design software has been used to stabilize proteins, solubilize membrane proteins, design intermolecular interactions, and design new protein structures. A key motivation for these studies is that they test our understanding of protein energetics and structure. De novo design of novel structures is a particularly rigorous test because the protein backbone must be designed in addition to… CONTINUE READING

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