Computer-assisted engineering of the synthetic pathway for biodegradation of a toxic persistent pollutant.

@article{Kurumbang2014ComputerassistedEO,
  title={Computer-assisted engineering of the synthetic pathway for biodegradation of a toxic persistent pollutant.},
  author={Nagendra Prasad Kurumbang and Pavel Dvor{\'a}k and Jaroslav Bendl and Jan Brezovsky and Zbynek Prokop and Jir{\'i} Damborsk{\'y}},
  journal={ACS synthetic biology},
  year={2014},
  volume={3 3},
  pages={172-81}
}
Anthropogenic halogenated compounds were unknown to nature until the industrial revolution, and microorganisms have not had sufficient time to evolve enzymes for their degradation. The lack of efficient enzymes and natural pathways can be addressed through a combination of protein and metabolic engineering. We have assembled a synthetic route for conversion… CONTINUE READING