Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31.

@article{Hirschhorn2002ComputerAC,
  title={Computer assisted cloning of human neutral alpha-glucosidase C (GANC): a new paralog in the glycosyl hydrolase gene family 31.},
  author={Rochelle Hirschhorn and Maryann L. Huie and Jocelyn S. Kasper},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 21},
  pages={13642-6}
}
The exponential expansion of the publicly available human DNA sequence database has increasingly facilitated cloning by homology of genes for biochemically defined, functionally similar proteins. We hypothesized that an as-yet uncloned human alpha-glucosidase (human neutral alpha-glucosidase C or GANC) is a previously uncharacterized member of a paralogous human glycosyl hydrolase gene family 31, sharing sequence homology and related, but not identical, functions with other cloned human alpha… CONTINUE READING