Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.

@article{Koonin1992ComputerassistedAO,
  title={Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.},
  author={E. Koonin and A. Gorbalenya and M. Purdy and M. Rozanov and G. Reyes and D. Bradley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 17},
  pages={
          8259-63
        }
}
Computer-assisted comparison of the nonstructural polyprotein of hepatitis E virus (HEV) with proteins of other positive-strand RNA viruses allowed the identification of the following putative functional domains: (i) RNA-dependent RNA polymerase, (ii) RNA helicase, (iii) methyltransferase, (iv) a domain of unknown function ("X" domain) flanking the papain-like protease domains in the polyproteins of animal positive-strand RNA viruses, and (v) papain-like cysteine protease domain distantly… Expand
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