The last five years have seen the rapid development of computer assisted surgery (CAS) in total knee replacement (TKR). Many surgeons perform TKR using navigation systems, which offer user-friendly workflows and reproducible results. A number of level 1 and 2 studies, according to evidence-based medicine criteria, have demonstrated that navigation in TKR allows a more precise implantation of the prosthesis, though CAS still requires an experienced surgeon and is time consuming. Nevertheless, 30% of surgeons in Germany who perform TKR have used navigation. It is still not known whether this new technique improves the longevity of TKR, however, and we therefore performed a meta-analysis to assess the results of this new health care technology.