Computer aided subunit vaccine design against pathogenic Leptospira serovars

  title={Computer aided subunit vaccine design against pathogenic Leptospira serovars},
  author={Amineni Umamaheswari and Dibyabhaba Pradhan and Marisetty Hemanthkumar},
  journal={Interdisciplinary Sciences: Computational Life Sciences},
Epitopes of Leptospira inducing CD4+ T-cell responses by binding to human MHC molecules could critically contribute to the development of subunit vaccines for leptospirosis. Herein, we have identified unique vaccine peptides from outer membrane proteins (OMPs) common to four sequenced pathogenic Leptospira serovars through in silico reverse vaccinology technique. The OMPs were explored for probable antigens using jemboss and screened in ProPred subsequently to predict thirty HLA-DRB epitopes… CONTINUE READING
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