• Chemistry, Medicine
  • Published in Chemical Society reviews 2005
  • DOI:10.1039/B104620A

Computer-aided organic synthesis.

  title={Computer-aided organic synthesis.},
  author={Matthew H. Todd},
  journal={Chemical Society reviews},
  volume={34 3},
It is tempting for those in the field of organic synthesis to liken the process of retrosynthesis to a game of chess. That the world chess champion was recently defeated by a computer leads us to think that perhaps new and powerful computing methods could be applied to synthetic problems. Here the analogy between synthesis and chess is outlined. Achievements in the 35-year history of computer-aided synthetic design are described, followed by some more recent developments. 

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