Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate.

@article{Glass2006ComputeraidedDO,
  title={Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate.},
  author={John O. Glass and Wilburn E. Reddick and Chin-Shang Li and Fred H. Laningham and Kathleen J. Helton and Ching-Hon Pui},
  journal={Magnetic resonance imaging},
  year={2006},
  volume={24 6},
  pages={
          785-91
        }
}
The purpose of this study was to use objective quantitative magnetic resonance imaging (MRI) methods to develop a computer-aided detection (CAD) tool to differentiate white matter (WM) hyperintensities into either leukoencephalopathy (LE) induced by chemotherapy or normal maturational processes in children treated for acute lymphoblastic leukemia without irradiation. A combined MRI set consisting of T1-weighted, T2-weighted, proton-density-weighted and fluid-attenuated inversion recovery images… CONTINUE READING
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