Computer-Based De Novo Designs of Tripeptides as Novel Neuraminidase Inhibitors

Abstract

The latest influenza A (H1N1) pandemic attracted worldwide attention and called for the urgent development of novel antiviral drugs. Here, seven tripeptides are designed and explored as neuraminidase (NA) inhibitors on the structural basis of known inhibitors. Their interactions with NA are studied and compared with each other, using flexible docking and… (More)
DOI: 10.3390/ijms11124932

Topics

7 Figures and Tables