Computer-Assisted Continuous Infusion of the Intravenous Analgesic Fentanyl During General Anesthesia-An Interactive System

@article{Alvis1985ComputerAssistedCI,
  title={Computer-Assisted Continuous Infusion of the Intravenous Analgesic Fentanyl During General Anesthesia-An Interactive System},
  author={J. M. Alvis and Joseph G. Reves and J. A. Spain and Louis C. Sheppard},
  journal={IEEE Transactions on Biomedical Engineering},
  year={1985},
  volume={BME-32},
  pages={323-329}
}
A computer-assisted continuous infusion (CACI) system which would rapidly attain and maintain a constant plasma level (i.e., constant set point) of the opiod, fentanyl, was designed. This open-loop CACI system was then modified to allow the anesthesiologist (clinician) to adjust the plasma level (set point) intraoperatively (i. e., a variable set point); however, since no sensor is presently available to measure the plasma concentration of fentanyl on line, a mathematical model was implemented… CONTINUE READING

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