Computed tomography of virally induced canine brain tumors: a preliminary report.


Seven neonatal dogs were inoculated intracerebrally with Avian Sarcoma Virus (ASV) and studied by computed tomography (CT) for intracranial tumors. The tumor yield was five anaplastic astrocytomas and two sarcomas, with an average latency of 57 days. Computed tomography accurately detected all tumors over 5 mm in diameter and predicted the size of the tumors within 3 mm. The intensity of contrast enhancement was directly related to the dose of Conray-60. The area of enhancement on the CT scan correlated precisely with tumor permeability as determined histologically with horseradish peroxidase (HRP). Edema seen in CT scans correlated well with edema present in histological sections. Peritumoral edema was impermeable to both Conray-60 and HRP. The ASV-induced canine brain tumor model appears well suited for future CT studies.


Citations per Year

876 Citations

Semantic Scholar estimates that this publication has 876 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Groothuis1981ComputedTO, title={Computed tomography of virally induced canine brain tumors: a preliminary report.}, author={Dennis R . Groothuis and Michael A Mikhael and Joan M. Fischer and Joseph F. Pasternak and Terry Fouts and Darell D Bigner and Nicholas A. Vick}, journal={Journal of computer assisted tomography}, year={1981}, volume={5 4}, pages={538-43} }