Computed 88% TCP dose for SBRT of NSCLC from tumour hypoxia modelling.

@article{Ruggieri2013Computed8T,
  title={Computed 88% TCP dose for SBRT of NSCLC from tumour hypoxia modelling.},
  author={Ruggero Ruggieri and Nadejda Stavreva and Stefania Naccarato and Pavel V Stavrev},
  journal={Physics in medicine and biology},
  year={2013},
  volume={58 13},
  pages={4611-20}
}
In small NSCLC, 88% local control at three years from SBRT was reported both for schedule (20-22 Gy ×3) (Fakiris et al 2009 Int. J. Radiat. Oncol. Biol. Phys. 75 677-82), actually close to (18-20 Gy ×3) if density correction is properly applied, and for schedules (18 Gy ×3) and (11 Gy ×5) (Palma et al 2012 Int. J. Radiat. Oncol. Biol. Phys. 82 1149-56). Here, we compare our computed iso-TCP = 88% dose per fraction (d88) for three and five fractions (n) with such clinically adopted ones. Our TCP… CONTINUE READING
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