Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate

  title={Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate},
  author={Regina S. Salvat and Andrew S. Parker and Andrew Guilliams and Yoonjoo Choi and Chris Bailey-Kellogg and Karl E. Griswold},
  journal={Cellular and Molecular Life Sciences},
Biotherapeutics are subject to immune surveillance within the body, and anti-biotherapeutic immune responses can compromise drug efficacy and patient safety. Initial development of targeted antidrug immune memory is coordinated by T cell recognition of immunogenic subsequences, termed “T cell epitopes.” Biotherapeutics may therefore be deimmunized by mutating key residues within cognate epitopes, but there exist complex trade-offs between immunogenicity, mutational load, and protein structure… CONTINUE READING
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