Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate

@article{Salvat2014ComputationallyDD,
  title={Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate},
  author={Regina S. Salvat and Andrew S. Parker and Andrew Guilliams and Yoonjoo Choi and Chris Bailey-Kellogg and Karl E. Griswold},
  journal={Cellular and Molecular Life Sciences},
  year={2014},
  volume={71},
  pages={4869-4880}
}
Biotherapeutics are subject to immune surveillance within the body, and anti-biotherapeutic immune responses can compromise drug efficacy and patient safety. Initial development of targeted antidrug immune memory is coordinated by T cell recognition of immunogenic subsequences, termed “T cell epitopes.” Biotherapeutics may therefore be deimmunized by mutating key residues within cognate epitopes, but there exist complex trade-offs between immunogenicity, mutational load, and protein structure… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Pareto optimization of combinatorial mutagenesis libraries.

IEEE/ACM transactions on computational biology and bioinformatics • 2018

References

Publications referenced by this paper.
Showing 1-10 of 41 references

ProPred: prediction of HLA-DR binding sites

Bioinformatics • 2001
View 4 Excerpts
Highly Influenced

Design and analysis of immune-evading enzymes for ADEPT therapy.

Protein engineering, design & selection : PEDS • 2012
View 10 Excerpts

Similar Papers

Loading similar papers…