Computationally Aided Absolute Stereochemical Determination of Enantioenriched Amines.

@article{Zhang2017ComputationallyAA,
  title={Computationally Aided Absolute Stereochemical Determination of Enantioenriched Amines.},
  author={Jun Zhang and Hadi Gholami and Xinliang Ding and Minji Chun and Chrysoula Vasileiou and Tatsuo Nehira and Babak Borhan},
  journal={Organic letters},
  year={2017},
  volume={19 6},
  pages={
          1362-1365
        }
}
A simple and efficient protocol for sensing the absolute stereochemistry and enantiomeric excess of chiral monoamines is reported. Preparation of the sample requires a single-step reaction of the 1,1'-(bromomethylene)dinaphthalene (BDN) with the chiral amine. Analysis of the exciton coupled circular dichroism generated from the BDN-derivatized chiral amine… CONTINUE READING