Computational studies of the electronic, conductivities, and spectroscopic properties of hydrolysed Ru(II) anticancer complexes.

@article{Adeniyi2013ComputationalSO,
  title={Computational studies of the electronic, conductivities, and spectroscopic properties of hydrolysed Ru(II) anticancer complexes.},
  author={Adebayo A Adeniyi and Peter A Ajibade},
  journal={Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
  year={2013},
  volume={115},
  pages={
          426-36
        }
}
The mechanism of activation of metal-based anticancer agents was reported to be through hydrolysis. In this study, computational method was used to gain insight to the correlation between the chemistry of the hydrolysis and the anticancer activities of selected Ru(II)-based complexes. Interestingly, we observed that the mechanism of activation by hydrolysis and their consequential anticancer activities is associated with favourable thermodynamic changes, higher hyperpolarizability (β), lower… CONTINUE READING
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