Computational simulations of stem-cell factor/c-kit receptor interaction.

  title={Computational simulations of stem-cell factor/c-kit receptor interaction.},
  author={Maria Cristina Menziani and Francesca Fanelli and Pier Giuseppe De Benedetti},
  volume={26 1},
Stem-cell factor (SCF) is a noncovalent homodimeric cytokine that exhibits profound biological function in the early stages of hematopoiesis by binding to a cell surface tyrosine kinase receptor that is encoded by the c-Kit proto-oncogene. The results obtained from a combined implementation of homology-based molecular modeling and computational simulations… CONTINUE READING