Computational sequence analysis of the tissue inhibitor of metalloproteinase family.

@article{Douglas1997ComputationalSA,
  title={Computational sequence analysis of the tissue inhibitor of metalloproteinase family.},
  author={Dr. A. J. Douglas and Yeunian E Shi and Qing-Xiang Amy Sang},
  journal={Journal of protein chemistry},
  year={1997},
  volume={16 4},
  pages={237-55}
}
The tissue inhibitor of metalloproteinase (TIMP) family regulates extracellular matrix turnover and tissue remodeling by forming tight-binding inhibitory complexes with matrix metalloproteinases (MMPs). MMPs and TIMPs have been implicated in many normal and pathological processes, such as morphogenesis, development, angiogenesis, and cancer metastasis. This minireview provides information that would aid in classification of the TIMP family and in understanding the similarities and differences… CONTINUE READING
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