Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease.

@article{Dudley2011ComputationalRO,
  title={Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease.},
  author={Joel T. Dudley and Marina Sirota and Mohan Shenoy and Reetesh K Pai and Silke Roedder and Annie P. Chiang and Alexander A. Morgan and Minnie M. Sarwal and Pankaj Jay Pasricha and Atul J Butte},
  journal={Science translational medicine},
  year={2011},
  volume={3 96},
  pages={96ra76}
}
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract for which there are few safe and effective therapeutic options for long-term treatment and disease maintenance. Here, we applied a computational approach to discover new drug therapies for IBD in silico, using publicly available molecular data reporting gene expression in IBD samples and 164 small-molecule drug compounds. Among the top compounds predicted to be therapeutic for IBD by our approach… CONTINUE READING