Computational prediction of the human-microbial oral interactome

  title={Computational prediction of the human-microbial oral interactome},
  author={Edgar D. Coelho and Joel Arrais and S{\'e}rgio Matos and Carlos Pereira and Nuno Rosa and Maria Jos{\'e} Correia and Marlene Barros and Jos{\'e} Lu{\'i}s Oliveira},
  booktitle={BMC Systems Biology},
The oral cavity is a complex ecosystem where human chemical compounds coexist with a particular microbiota. However, shifts in the normal composition of this microbiota may result in the onset of oral ailments, such as periodontitis and dental caries. In addition, it is known that the microbial colonization of the oral cavity is mediated by protein-protein interactions (PPIs) between the host and microorganisms. Nevertheless, this kind of PPIs is still largely undisclosed. To elucidate these… CONTINUE READING
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