Computational prediction of human proteins that can be secreted into the bloodstream

@article{Cui2008ComputationalPO,
  title={Computational prediction of human proteins that can be secreted into the bloodstream},
  author={Juan Cui and Qi Liu and David Puett and Ying Xu},
  journal={Bioinformatics},
  year={2008},
  volume={24 20},
  pages={
          2370-5
        }
}
We present a novel computational method for predicting which proteins from highly and abnormally expressed genes in diseased human tissues, such as cancers, can be secreted into the bloodstream, suggesting possible marker proteins for follow-up serum proteomic studies. A main challenging issue in tackling this problem is that our understanding about the downstream localization after proteins are secreted outside the cells is very limited and not sufficient to provide useful hints about… CONTINUE READING
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