Computational models of basal ganglia dysfunction: the dynamics is in the details.

@article{Rubin2017ComputationalMO,
  title={Computational models of basal ganglia dysfunction: the dynamics is in the details.},
  author={Jonathan E. Rubin},
  journal={Current opinion in neurobiology},
  year={2017},
  volume={46},
  pages={
          127-135
        }
}
The development, simulation, and analysis of mathematical models offer helpful tools for integrating experimental findings and exploring or suggesting possible explanatory mechanisms. As models relating to basal ganglia dysfunction have proliferated, however, there has not always been consistency among their findings. This work points out several ways in which biological details, relating to ionic currents and synaptic pathways, can influence the dynamics of models of the basal ganglia under… CONTINUE READING