Computational models for predicting interactions with cytochrome p450 enzyme.

  title={Computational models for predicting interactions with cytochrome p450 enzyme.},
  author={Rieko Arimoto},
  journal={Current topics in medicinal chemistry},
  volume={6 15},
  • Rieko Arimoto
  • Published 2006 in Current topics in medicinal chemistry
Cytochrome p450 (CYP) enzymes are predominantly involved in Phase 1 metabolism of xenobiotics. As only 6 isoenzymes are responsible for approximately 90 % of known oxidative drug metabolism, a number of frequently prescribed drugs share the CYP-mediated metabolic pathways. Competing for a single enzyme by the co-administered therapeutic agents can substantially alter the plasma concentration and clearance of the agents. Furthermore, many drugs are known to inhibit certain p450 enzymes which… CONTINUE READING

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