Computational modelling of cellular level metabolism

  title={Computational modelling of cellular level metabolism},
  author={Daniela Calvetti and Jenni Heino and Erkki Somersalo},
The steady and stationary state inverse problems consist of estimating the reaction and transport fluxes, blood concentrations and possibly the rates of change of some of the concentrations based on data which are often scarce noisy and sampled over a population. The Bayesian framework provides a natural setting for the solution of this inverse problem, because a priori knowledge about the system itself and the unknown reaction fluxes and transport rates can compensate for the insufficiency of… CONTINUE READING