Computational modeling reveals molecular details of epidermal growth factor binding

@article{Mayawala2005ComputationalMR,
  title={Computational modeling reveals molecular details of epidermal growth factor binding},
  author={Kapil Mayawala and Dionisios G Vlachos and Jeremy S Edwards},
  journal={BMC Cell Biology},
  year={2005},
  volume={6},
  pages={41 - 41}
}
The ErbB family of receptors are dysregulated in a number of cancers, and the signaling pathway of this receptor family is a critical target for several anti-cancer drugs. Therefore a detailed understanding of the mechanisms of receptor activation is critical. However, despite a plethora of biochemical studies and recent single particle tracking experiments, the early molecular mechanisms involving epidermal growth factor (EGF) binding and EGF receptor (EGFR) dimerization are not as well… CONTINUE READING

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