Computational modeling of structure-function of g protein-coupled receptors with applications for drug design.

@article{Li2010ComputationalMO,
  title={Computational modeling of structure-function of g protein-coupled receptors with applications for drug design.},
  author={Yang Yang Li and Ting Hou and Wllliam A. Goddard},
  journal={Current medicinal chemistry},
  year={2010},
  volume={17 12},
  pages={
          1167-80
        }
}
G protein-coupled receptors (GPCRs) mediate senses such as odor, taste, vision, and pain in mammals. In addition, important cell recognition and communication processes often involve GPCRs. Many diseases involve malfunction of GPCRs, making them important targets for drug development. Indeed, greater than 50 % of all marketed therapeutics act on those receptors. Unfortunately, the atomic-level structures are only available for rhodopsin, beta2AR, beta1AR, A2A adenosin and opsin. In silico… CONTINUE READING

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PainNo subtypeEsthesia
G protein - coupled receptors ( GPCRs ) mediate senses such as odor , taste , vision , and pain in mammals .
EsthesiaNo subtypePain
G protein - coupled receptors ( GPCRs ) mediate senses such as odor , taste , vision , and pain in mammals .
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