Computational modeling of serum-binding proteins and clearance in extrapolations across life stages and species for endocrine active compounds.

@article{Teeguarden2004ComputationalMO,
  title={Computational modeling of serum-binding proteins and clearance in extrapolations across life stages and species for endocrine active compounds.},
  author={Justin G. Teeguarden and Hugh A. Barton},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={2004},
  volume={24 3},
  pages={
          751-70
        }
}
One measure of the potency of compounds that lead to the effects through ligand-dependent gene transcription is the relative affinity for the critical receptor. Endocrine active compounds that are presumed to act principally through binding to the estrogen receptor (e.g., estradiol, genistein, bisphenol A, and octylphenol) comprise one class of such compounds. For making simple comparisons, receptor-binding affinity has been equated to in vivo potency, which consequently defines the dose… CONTINUE READING
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