Computational modeling of morphogenesis regulated by mechanical feedback.

  title={Computational modeling of morphogenesis regulated by mechanical feedback.},
  author={Ashok Ramasubramanian and Larry A. Taber},
  journal={Biomechanics and modeling in mechanobiology},
  volume={7 2},
Mechanical forces cause changes in form during embryogenesis and likely play a role in regulating these changes. This paper explores the idea that changes in homeostatic tissue stress (target stress), possibly modulated by genes, drive some morphogenetic processes. Computational models are presented to illustrate how regional variations in target stress can cause a range of complex behaviors involving the bending of epithelia. These models include growth and cytoskeletal contraction regulated… CONTINUE READING