Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine.

Chronic cocaine administration causes instability in extracellular glutamate in the nucleus accumbens that is thought to contribute to the vulnerability to relapse. A computational framework was developed to model glutamate in the extracellular space, including synaptic and nonsynaptic glutamate release, glutamate elimination by glutamate transporters and… (More)