Computational method for inferring objective function of glycerol metabolism in Klebsiella pneumoniae

  title={Computational method for inferring objective function of glycerol metabolism in Klebsiella pneumoniae},
  author={Zhaohua Gong and Chongyang Liu and Enmin Feng and Qingrui Zhang},
  journal={Computational biology and chemistry},
  volume={33 1},
Flux balance analysis (FBA) is an effective tool in the analysis of metabolic network. It can predict the flux distribution of engineered cells, whereas the accurate prediction depends on the reasonable objective function. In this work, we propose two nonlinear bilevel programming models on anaerobic glycerol metabolism in Klebsiella pneumoniae (K. pneumoniae) for 1,3-propanediol (1,3-PD) production. One intends to infer the metabolic objective function, and the other is to analyze the… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 25 references

Optimization of microbial production of 1,3-propanediol by Klebsiella pneumoniae under anaerobic and microaerobic conditions by metabolic flux analysis

  • Q. R. Zhang, Z. L. Xiu, A. P. Zeng
  • J. Chem. Ind. Eng
  • 2006
1 Excerpt

Practical Bilevel Optimization: Algorithm and Application (Series Nonconvex Optimization and its Application)

  • J. F. Bard
  • 2006
1 Excerpt

Comparative study of flux redistribution of metabolic pathway in glutamate production by two coryneform bacteria

  • T. Shirai, A Nakato
  • Metab. Eng
  • 2005

Metabolic flux analysis of recombinant protein overproduction in Escherichia coli

  • P. Ozkan, B Sariyar
  • Biochem. Eng. J
  • 2005

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