Computational investigation of theoretical models of cleavable and uncleavable mucin 1 isoforms.

Abstract

Mucin 1 is an important tumor marker, and is notable for the autoproteolytic event, a signature of all SEA domain containing proteins. However the isoform MUC1/Y, unlike its closest counterpart MUC1/X, is noted to be uncleavable despite the presence of the catalytic site. Sequence analysis has revealed the presence of an 18 residue segment spliced out from… (More)
DOI: 10.1039/c3mb70200f

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