Computational insights into the selectivity mechanism of APP-IP over matrix metalloproteinases

Abstract

In this work, selectivity mechanism of APP-IP inhibitor (β-amyloid precursor protein-derived inhibitory peptide) over matrix metalloproteinases (MMPs including MMP-2, MMP-7, MMP-9 and MMP-14) was investigated by molecular modeling methods. Among MMPs, MMP-2 is the most favorable one for APP-IP interacting based on our calculations. The predicted binding… (More)
DOI: 10.1007/s10822-012-9617-3

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