Computational inference of the molecular logic for synaptic connectivity in C. elegans

@article{Varadan2006ComputationalIO,
  title={Computational inference of the molecular logic for synaptic connectivity in C. elegans},
  author={Vinay Varadan and David M. Miller and Dimitris Anastassiou},
  journal={Bioinformatics},
  year={2006},
  volume={22 14},
  pages={e497-506}
}
MOTIVATION The nematode C. elegans is an ideal model organism in which to investigate the biomolecular mechanisms underlying the connectivity of neurons, because synaptic connections are described in a comprehensive wiring diagram and methods for defining gene expression profiles of individual neurons are now available. RESULTS Here we present computational techniques linking these two types of information. A systems-based approach (EMBP: Entropy Minimization and Boolean Parsimony) identifies… CONTINUE READING
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