Computational inference of homologous gene structures in the human genome.

@article{Yeh2001ComputationalIO,
  title={Computational inference of homologous gene structures in the human genome.},
  author={R F Yeh and Lee Ping Lim and Christopher B. Burge},
  journal={Genome research},
  year={2001},
  volume={11 5},
  pages={
          803-16
        }
}
With the human genome sequence approaching completion, a major challenge is to identify the locations and encoded protein sequences of all human genes. To address this problem we have developed a new gene identification algorithm, GenomeScan, which combines exon-intron and splice signal models with similarity to known protein sequences in an integrated model. Extensive testing shows that GenomeScan can accurately identify the exon-intron structures of genes in finished or draft human genome… CONTINUE READING

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