Computational inference of homologous gene structures in the human genome.

  title={Computational inference of homologous gene structures in the human genome.},
  author={Rufang Yeh and Lee P. Lim and Christopher B. Burge},
  journal={Genome research},
  volume={11 5},
With the human genome sequence approaching completion, a major challenge is to identify the locations and encoded protein sequences of all human genes. To address this problem we have developed a new gene identification algorithm, GenomeScan, which combines exon-intron and splice signal models with similarity to known protein sequences in an integrated model. Extensive testing shows that GenomeScan can accurately identify the exon-intron structures of genes in finished or draft human genome… CONTINUE READING
Highly Influential
This paper has highly influenced 24 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 209 extracted citations

Similar Papers

Loading similar papers…