Computational identification of transcription factor binding sites via a transcription-factor-centric clustering (TFCC) algorithm.

@article{Zhu2002ComputationalIO,
  title={Computational identification of transcription factor binding sites via a transcription-factor-centric clustering (TFCC) algorithm.},
  author={Zhou Shuo Zhu and Yitzhak Pilpel and George M. Church},
  journal={Journal of molecular biology},
  year={2002},
  volume={318 1},
  pages={71-81}
}
While microarray-based expression profiling has facilitated the use of computational methods to find potential cis-regulatory promoter elements, few current in silico approaches explicitly link regulatory motifs with the transcription factors that bind them. We have thus developed a TF-centric clustering (TFCC) algorithm that may provide such missing information through incorporation of biological knowledge about TFs. TFCC is a semi-supervised clustering algorithm which relies on the assumption… CONTINUE READING
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