Computational identification of operons in microbial genomes.

  title={Computational identification of operons in microbial genomes.},
  author={Yu Zheng and Joseph D. Szustakowski and Lance Fortnow and R. J. Roberts and Simon Kasif},
  journal={Genome research},
  volume={12 8},
By applying graph representations to biochemical pathways, a new computational pipeline is proposed to find potential operons in microbial genomes. The algorithm relies on the fact that enzyme genes in operons tend to catalyze successive reactions in metabolic pathways. We applied this algorithm to 42 microbial genomes to identify putative operon structures. The predicted operons from Escherichia coli were compared with a selected metabolism-related operon dataset from the RegulonDB database… CONTINUE READING
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