Computational identification of gene-social environment interaction at the human IL6 locus.

@article{Cole2010ComputationalIO,
  title={Computational identification of gene-social environment interaction at the human IL6 locus.},
  author={Steve W. Cole and Jesusa Arevalo and Rie Takahashi and Erica K. Sloan and Susan K Lutgendorf and Anil Sood and John F Sheridan and Teresa Seeman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 12},
  pages={
          5681-6
        }
}
To identify genetic factors that interact with social environments to impact human health, we used a bioinformatic strategy that couples expression array-based detection of environmentally responsive transcription factors with in silico discovery of regulatory polymorphisms to predict genetic loci that modulate transcriptional responses to stressful environments. Tests of one predicted interaction locus in the human IL6 promoter (SNP rs1800795) verified that it modulates transcriptional… CONTINUE READING

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