Computational explanation for bioactivation mechanism of targeted anticancer agents mediated by cytochrome P450s: A case of Erlotinib

Abstract

EGFR inhibitors, even with therapeutics superiorities in anticancer, can cause idiosyncratic pulmonary and hepatic toxicities that are associated with the reactive electrophile bioactivated by Cytochrome P450s (P450s). Until now, neither has the electrophilic intermediate been caught experimentally, nor has the subtle mechanism been declared. Herein, the… (More)
DOI: 10.1371/journal.pone.0179333

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Cite this paper

@inproceedings{Ai2017ComputationalEF, title={Computational explanation for bioactivation mechanism of targeted anticancer agents mediated by cytochrome P450s: A case of Erlotinib}, author={Chun-Zhi Ai and Yong Liu and Wei Li and De-Meng Chen and Xin-xing Zhu and Ya-Wei Yan and Du-Chu Chen and Yi-zhou Jiang}, booktitle={PloS one}, year={2017} }