Computational evaluation of TIS annotation for prokaryotic genomes

@article{Hu2007ComputationalEO,
  title={Computational evaluation of TIS annotation for prokaryotic genomes},
  author={Gang-Qing Hu and Xiaobin Zheng and Lining Arnold Ju and Huaiqiu Zhu and Zhen-Su She},
  journal={BMC Bioinformatics},
  year={2007},
  volume={9},
  pages={160 - 160}
}
BackgroundAccurate annotation of translation initiation sites (TISs) is essential for understanding the translation initiation mechanism. However, the reliability of TIS annotation in widely used databases such as RefSeq is uncertain due to the lack of experimental benchmarks.ResultsBased on a homogeneity assumption that gene translation-related signals are uniformly distributed across a genome, we have established a computational method for a large-scale quantitative assessment of the… CONTINUE READING

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Identifying translation initiation sites in prokaryotes using support vector machine.

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