Computational evaluation and experimental verification of antibacterial activity of some β-lactams: advantages and limitations

Abstract

Herein, mono and bicyclic β-lactams are computationally evaluated and experimentally verified for in vitro antimicrobial activity. The compounds prepared were tested against various Gram-positive and Gram-negative bacterial species such as Escherichia coli, Staphylococcus citrus, Klebsiella pneumoniae, and Bacillus subtilis. Some of these compounds show… (More)
DOI: 10.1007/s00044-012-0126-7

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