Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless.

Abstract

The Ras-specific nucleotide exchange factor son of sevenless (SOS) is a large, multidomain protein with complex regulation, including a Ras-dependent allosteric mechanism. The N-terminal segment of SOS, the histone domain, contains two histone folds, which is highly unusual for a cytoplasmic protein. Using a combination of computational docking, small-angle… (More)

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Cite this paper

@article{Sondermann2005ComputationalDA, title={Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless.}, author={Holger Sondermann and Bhushan Nagar and Dafna Bar-Sagi and John Kuriyan}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2005}, volume={102 46}, pages={16632-7} }