Computational detection and experimental validation of segmental duplications and associated copy number variations in water buffalo (Bubalus bubalis)

@article{Liu2019ComputationalDA,
  title={Computational detection and experimental validation of segmental duplications and associated copy number variations in water buffalo (Bubalus bubalis)},
  author={Shuli Liu and Xiaolong Kang and Claudia Rita Catacchio and Mei Liu and Lingzhao Fang and Steven G. Schroeder and Wenli Li and Benjamin D. Rosen and Daniela Iamartino and Leopoldo Iannuzzi and Tad S. Sonstegard and Curtis P Van Tassell and Mario Ventura and Wai Yee Low and John L. Williams and Derek M. Bickhart and George E. Liu},
  journal={Functional & Integrative Genomics},
  year={2019},
  volume={19},
  pages={409-419}
}
Duplicated sequences are an important source of gene evolution and structural variation within mammalian genomes. Using a read depth approach based on next-generation sequencing, we performed a genome-wide analysis of segmental duplications (SDs) and associated copy number variations (CNVs) in the water buffalo (Bubalus bubalis). By aligning short reads of Olimpia (the reference water buffalo) to the UMD3.1 cattle genome, we identified 1,038 segmental duplications comprising 44.6 Mb (equivalent… CONTINUE READING
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