Computational design of water-soluble analogues of the potassium channel KcsA.

@article{Slovic2004ComputationalDO,
  title={Computational design of water-soluble analogues of the potassium channel KcsA.},
  author={Avram M Slovic and Hidetoshi Kono and James D. Lear and Jeffery G. Saven and William F. DeGrado},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 7},
  pages={1828-33}
}
Although the interiors of membrane and water-soluble proteins are similar in their physicochemical properties, membrane proteins differ in having larger fractions of hydrophobic residues on their exteriors. Thus, it should be possible to water-solubilize membrane proteins by mutating their lipid-contacting side chains to more polar groups. Here, a computational approach was used to generate water-soluble variants of the potassium channel KcsA. As a probe of the correctness of the fold, the… CONTINUE READING

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Computational Design of Water - Soluble Analogues of the Potassium Channel KcsA

W. F. DeGrado
Proceedings of the National Academy of Sciences of the United States of America • 2004

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