Computational design of self-assembling protein nanomaterials with atomic level accuracy.


We describe a general computational method for designing proteins that self-assemble to a desired symmetric architecture. Protein building blocks are docked together symmetrically to identify complementary packing arrangements, and low-energy protein-protein interfaces are then designed between the building blocks in order to drive self-assembly. We used… (More)
DOI: 10.1126/science.1219364


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